The winning binder recipe flips every twelve months. Labs that built for the last one are still rebuilding.
2.5%
13.25%
A new design method lands every quarter. Each one is better on some target class, worse on others. The team that wins is the one that picks the right route per campaign. Not the team with the best single method.
Fast baseline routing for familiar target classes.
Generates candidate shapes when the starting structure is under-specified.
Builds target-specific binders from campaign constraints and interface goals.
Ranks sequences and structures against confidence and interface metrics.
Runs proprietary or unpublished methods inside the same campaign envelope.
Keeps human overrides, QC notes, and audit trails attached to each route.
You bring the protein. We pick the route.
Structure file, predicted structure, or sequence. Name the campaign goal.
Our allocator picks 2–4 runners from the rotation. You can override.
Run in parallel, ranked against interface and confidence metrics, returned top-N.
papercrane / cli $papercrane route --target IL2RA.pdb --campaign binders→parsing target 154 aa · single chain→selecting route backbone lane + binder lane→running 4 candidates parallel · 8m 14s→ranking outputs interface + confidence✓returned top-24 sequences
One contract per campaign.
Students, iGEM teams, undergraduates.
Grad students, postdocs, small academic labs.
Biotech teams, regulated environments.
Co-founder
Builds the frontend, brand, and marketing operations.
Co-founder
Builds the backend and the engineering that routes every campaign.
Tell us what you are designing. We respond within 48 hours.