§ The FoldRSS ↗

Notes from the workbench.

Benchmark releases, methodology essays, and engineering writing — paper-thin, fold-clean. Issue 01 lands with v1.0 of the benchmark.

Issue 01 · Benchmark

Why we benchmark on PD-L1, RBD, and IL-7Rα.

Three targets, three reasons. The case for a small, defensible benchmark over a sprawling, irreproducible one — and why the field has been measuring the wrong thing for two years.

Author
Harsha Poonepalle
Drops
May 2026
Length
11 min read
In edit · preview only
In the queue
  1. 02
    Engineering

    From Conda hell to one-line binders.

    How we packaged eight protein design tools behind one API — and what we lost, and kept, along the way.

    May 2026
    9 min
    Paper Crane team
  2. 03
    Methodology

    ipSAE vs ipTM vs pDockQ — what actually predicts binding.

    We ran 540 designs and asked which interface metric correlates with downstream wet-lab success. Spoiler: ipSAE wins, by a wider margin than expected.

    June 2026
    14 min
    Paper Crane team
  3. 04
    Field notes

    What we learned from 12,000 failed binders.

    An honest post-mortem of the misses — what the metrics caught, what they didn't, and the failure modes nobody publishes.

    July 2026
    Paper Crane team

Want first dibs on the writing?

Same address as the waitlist. We email Issue 01 when it ships, then nothing for a month at a time. No tracking pixels, no sequences.